Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease

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Item Type:	Article
Title:	Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease
Creators Name:	Wittenbecher, F., Rieger, K., Dziubianau, M., Herholz, A., Mensen, A., Blau, I.W., Uharek, L., Dörken, B., Thiel, A. and Na, I.K.
Abstract:	Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD.
Keywords:	HSCT, Antithymocyte Globulin, CD8 T Cell, Effector Memory, Naive
Source:	Leukemia Research Reports
ISSN:	2213-0489
Publisher:	Elsevier
Volume:	2
Number:	2
Page Range:	82-85
Date:	27 September 2013
Official Publication:	https://doi.org/10.1016/j.lrr.2013.09.001
PubMed:	View item in PubMed

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