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Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis

Item Type:Article
Title:Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis
Creators Name:Zhao, X. and Mohaupt, M. and Jiang, J. and Liu, S. and Li, B. and Qin, Z.
Abstract:Tumor necrosis factor (TNF) binds to two different receptors. Although most of its functions are attributed to TNF receptor 1 (TNFR1), the independent role of TNFR2 is still largely unknown. Using TNFR single or double knock-out mice, we show here that the expression of TNFR2 alone on host cells was sufficient to suppress the growth of TNF-secreting tumors in both immune competent and T/B lymphocyte-deficient severe combined immunodeficiency (SCID) mice. Histologic studies showed that TNF recruited, via TNFR2, large numbers of macrophages and efficiently inhibited angiogenesis in the tumor. In vitro, TNF activated TNFR1-deficient macrophages to produce nitric oxide (NO). Treatment of TNFR1 knock-out mice with L-NAME, a specific NO synthase inhibitor, almost completely eliminated TNF-induced angiostasis and tumor suppression. Moreover, L-NAME acted only during the first few days of tumor growth. Our results show for the first time that TNFR2 expressed on host innate immune cells is sufficient to mediate the antitumor effect of TNF, and NO is necessary for this process, possibly by inhibition of angiogenesis in the tumor.
Keywords:TNFR2, Macrophage, Nitric oxide, Tumor suppression, Angiostasis, Animals, Mice
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:67
Number:9
Page Range:4443-4450
Date:1 May 2007
Official Publication:https://doi.org/10.1158/0008-5472.CAN-07-0185
PubMed:View item in PubMed

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