A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme?

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Item Type:	Article
Title:	A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme?
Creators Name:	Koonin, E., Bork, P. and Sander, C.
Abstract:	Using computer methods for database search, multiple alignment, protein sequence motif analysis and secondary structure prediction, a putative new RNA-binding motif was identified. The novel motif is conserved in yeast omnipotent translation termination suppressor SUP1, the related DOM34 protein and its pseudogene homologue; three groups of eukaryotic and archaeal ribosomal proteins, namely L30e, L7Ae/S6e and S12e; an uncharacterized Bacillus subtilis protein related to the L7A/S6e group; and Escherichia coli ribosomal protein modification enzyme RimK. We hypothesize that a new type of RNA-binding domain may be utilized to deliver additional activities to the ribosome.
Keywords:	Amino Acid Sequence, Bacterial Proteins, Escherichia coli, Fungal Proteins, Molecular Sequence Data, Protein Biosynthesis, RNA, RNA-Binding Proteins, Ribosomal Proteins, Ribosomes, Animals
Source:	Nucleic Acids Research
ISSN:	0305-1048
Publisher:	Oxford University Press
Volume:	22
Number:	11
Page Range:	2166-2167
Date:	11 June 1994
Official Publication:	https://doi.org/10.1093/nar/22.11.2166
PubMed:	View item in PubMed

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