Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

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Item Type:	Article
Title:	Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis
Creators Name:	Roth, N.M., Saidha, S., Zimmermann, H., Brandt, A.U., Oberwahrenbrock, T., Maragakis, N.J., Tumani, H., Ludolph, A.C., Meyer, T., Calabresi, P.A. and Paul, F.
Abstract:	BACKGROUND AND PURPOSE: In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) - with its potential to reveal neuroaxonal retinal damage - may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. METHODS: Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised. RESULTS: There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity. CONCLUSIONS: These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS.
Keywords:	Amyotrophic Lateral Sclerosis, Multisystem Disorder, Optical Coherence Tomography, Retina
Source:	European Journal of Neurology
ISSN:	1351-5101
Publisher:	Wiley-Blackwell
Volume:	20
Number:	8
Page Range:	1170-1176
Date:	August 2013
Official Publication:	https://doi.org/10.1111/ene.12146
PubMed:	View item in PubMed

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