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How anti-neutrophil cytoplasmic autoantibodies activate neutrophils

Item Type:Review
Title:How anti-neutrophil cytoplasmic autoantibodies activate neutrophils
Creators Name:Kettritz, R.
Abstract:Neutrophils are pivotal to host defence during infectious diseases. However, activated neutrophils may also cause undesired tissue damage. Ample examples include small-vessel inflammatory diseases (vasculitis) that are associated with anti-neutrophil cytoplasmic autoantibodies (ANCA) residing in the patients' plasma. In addition to being an important diagnostic tool, convincing evidence shows that ANCA are pathogenic. ANCA-neutrophil interactions induce important cellular responses that result in highly inflammatory necrotizing vascular damage. The interaction begins with ANCA binding to their target antigens on primed neutrophils, proceeds by recruiting transmembrane molecules to initiate intracellular signal transduction and culminates in activation of effector functions that ultimately mediate the tissue damage.
Keywords:ANCA, Neutrophils, Pathogenesis, Signal Transduction, Vasculitis, Animals
Source:Clinical and Experimental Immunology
Publisher:Wiley-Blackwell (U.K.)
Page Range:220-228
Date:September 2012
Official Publication:https://doi.org/10.1111/j.1365-2249.2012.04615.x
PubMed:View item in PubMed

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