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| Item Type: | Article |
|---|---|
| Title: | Elevated Bcl-X(L) levels correlate with T cell survival in multiple sclerosis |
| Creators Name: | Waiczies, S., Weber, A., Luenemann, J.D., Aktas, O., Zschenderlein, R. and Zipp, F. |
| Abstract: | T cell resistance towards apoptotic elimination by activation-induced cell death (AICD) might be a crucial pathogenic feature of multiple sclerosis (MS). Since the Bcl-2 family is critically involved in the regulation of apoptosis, we investigated the protein expression of Bcl-2, Bcl-X(L), and Bax in peripheral blood mononuclear cells (PBMC) of 23 MS patients and 29 control subjects. An in vitro model of AICD, which exemplifies the elimination of antigen-reactive T cells in vivo, was used as an indication of T cell susceptibility or resistance towards apoptosis. Increased expression of the survival factor Bcl-X(L), which directly correlated with a resistance towards AICD, was observed in peripheral immune cells of MS patients. In contrast to Bcl-X(L), no differences were found in the protein expression of Bcl-2 and Bax between patients and controls. Our data indicate that the anti-apoptotic factor Bcl-X(L), responsible for T cell resistance towards apoptosis, might be an important factor in the MS pathogenesis and a potential target for therapeutic intervention. |
| Keywords: | Bcl-XL, Activation-Induced Cell Death, Multiple Sclerosis |
| Source: | Journal of Neuroimmunology |
| ISSN: | 0165-5728 |
| Publisher: | Elsevier |
| Volume: | 126 |
| Number: | 1-2 |
| Page Range: | 213-220 |
| Date: | May 2002 |
| Official Publication: | https://doi.org/10.1016/S0165-5728(02)00067-X |
| PubMed: | View item in PubMed |
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