An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect

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Item Type:	Article
Title:	An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
Creators Name:	Fraga-Silva, R.A., Costa-Fraga, F.P., Sousa, F.B., Alenina, N., Bader, M., Sinisterra, R.D. and Santos, R.A.
Abstract:	The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect of angiotensin-(1-7) involves receptor Mas-mediated NO-release from platelets. Here, we describe an orally active formulation based on angiotensin-(1-7) inclusion in cyclodextrin [Ang-(1-7)- CyD] as an antithrombotic agent. Cyclodextrins are pharmaceutical tools that are used to enhance drug stability, absorption across biological barriers and gastric protection.
Keywords:	Angiotensin-(1-7), Renin-Angiotensin-System, Receptor Mas, Antithrombotic, Cyclodextrin, Animals, Mice, Rats
Source:	Clinics
ISSN:	1807-5932
Publisher:	University of Sao Paulo, Faculty of Medicine
Volume:	66
Number:	5
Page Range:	837-841
Date:	2011
Official Publication:	https://doi.org/10.1590/S1807-59322011000500021
PubMed:	View item in PubMed

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