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| Item Type: | Review |
|---|---|
| Title: | Notch and NF-κB signaling pathways in the biology of classical Hodgkin lymphoma |
| Creators Name: | Schwarzer, R. and Jundt, F. |
| Abstract: | Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression pattern and recurrent genetic lesions. Aberrant activity of Notch signaling, a highly conserved developmental pathway, acts as a negative regulator of the B cell program in HRS cells and thereby contributes to their reprogramming. Another striking feature and the major pathogenetic mechanism in HRS cells is constitutive NF-κB activation. A number of aberrations that contribute to canonical NF-κB activity in HRS cells have been described such as genetic lesions, deregulated receptor signaling and Epstein-Barr virus (EBV) infection. The importance of Notch and NF-κB signaling for cHL pathogenesis, their potential cross-talk and implications for future therapeutic applications are being discussed. |
| Keywords: | Notch, NF-κB, Hodgkin Lymphoma, B Cell Lymphoma, Hodgkin/Reed-Sternberg Cells, Gene Transcription, Mutations, Immunoprecipitation, Inflammatory Cells, Cytokine, Helix-Loop-Helix Proteins, Epstein-Barr Virus, Multiple Myeloma, B-Chronic Lymphocytic Leukemia, Tumor Suppressor Gene, Animals |
| Source: | Current Molecular Medicine |
| ISSN: | 1566-5240 |
| Publisher: | Bentham |
| Volume: | 11 |
| Number: | 3 |
| Page Range: | 236-245 |
| Date: | April 2011 |
| Official Publication: | https://doi.org/10.2174/156652411795243423 |
| PubMed: | View item in PubMed |
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