Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?

Item Type:Article
Title:Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?
Creators Name:Drogan, D., Weikert, C., Dierkes, J., Klipstein-Grobusch, K., Buijsse, B., Moehlig, M., Pfeiffer, A.F., Pischon, T., Spranger, J. and Boeing, H.
Abstract:Objective-To investigate the interrelation between plasma {gamma}-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Methods and Results-Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk. Conclusion-The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated.
Keywords:{gamma}-Glutamyltransferase, Cysteinyl-Glycine, Oxidized LDL, Myocardial Infarction, Prospective Study
Source:Arteriosclerosis Thrombosis and Vascular Biology
ISSN:1079-5642
Publisher:American Heart Association
Volume:30
Number:10
Page Range:2053-2058
Date:October 2010
Official Publication:https://doi.org/10.1161/ATVBAHA.110.209346
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library