Tumor necrosis factor (TNF)-alpha, soluble TNF receptors and endometrial cancer risk: The EPIC study

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Item Type:	Article
Title:	Tumor necrosis factor (TNF)-alpha, soluble TNF receptors and endometrial cancer risk: The EPIC study
Creators Name:	Dossus, L., Becker, S., Rinaldi, S., Lukanova, A., Tjønneland, A., Olsen, A., Overvad, K., Chabbert-Buffet, N., Boutron-Ruault, M.C., Clavel-Chapelon, F., Teucher, B., Chang-Claude, J., Pischon, T., Boeing, H., Trichopoulou, A., Benetou, V., Valanou, E., Palli, D., Sieri, S., Tumino, R., Sacerdote, C., Galasso, R., Redondo, M.L., Bonet Bonet, C., Molina-Montes, E., Altzibar, J.M., Chirlaque, M.D., Ardanaz, E., Bueno-de-Mesquita, H.B., van Duijnhoven, F.J., Peeters, P.H., Onland-Moret, N.C., Lundin, E., Idahl, A., Khaw, K.T., Wareham, N., Allen, N., Romieu, I., Fedirko, V., Hainaut, P., Romaguera, D., Norat, T., Riboli, E. and Kaaks, R.
Abstract:	Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-alpha (TNF-alpha), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) to examine the association of TNF-alpha and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-alpha (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, P(trend)=0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, P(trend)=0.07), and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, P(trend)=0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated pre-diagnostic concentrations of TNF-alpha and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Keywords:	Tumor Necrosis Factor (TNF)-alpha, Soluble TNF Receptors, Inflammation, Endometrial Cancer, Prospective
Source:	International Journal of Cancer
ISSN:	0020-7136
Publisher:	Wiley
Volume:	129
Number:	8
Page Range:	2032-2037
Date:	15 October 2011
Official Publication:	https://doi.org/10.1002/ijc.25840
PubMed:	View item in PubMed

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