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Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

Item Type:Article
Title:Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
Creators Name:Jentsch, T.J., Steinmeyer, K. and Schwarz, G.
Abstract:A complementary DNA encoding a voltage-gated chloride channel from Torpedo marmorata electric organ was cloned by expressing hybrid-depleted messenger RNA in Xenopus oocytes. The predicted protein has a sequence of 805 amino acids containing several putative membrane-spanning domains. Expression of the protein in Xenopus oocytes shows that it is sufficient for channel function.
Keywords:Amino Acid Sequence, Base Sequence, Cell Membrane, Chloride Channels, Chlorides, Molecular Cloning, DNA, Electric Conductivity, Gene Expression, Membrane Proteins, Molecular Sequence Data, Oocytes, Messenger RNA, Solubility, Animals, Xenopus Laevis
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group
Volume:348
Number:6301
Page Range:510-514
Date:6 December 1990
Official Publication:https://doi.org/10.1038/348510a0
PubMed:View item in PubMed

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