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Cellular uptake of steroid carrier proteins - mechanisms and implications

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Item Type:Review
Title:Cellular uptake of steroid carrier proteins - mechanisms and implications
Creators Name:Willnow, T.E. and Nykjaer, A.
Abstract:Steroid hormones are believed to enter cells solely by free diffusion through the plasma membrane. However, recent studies suggest the existence of cellular uptake pathways for carrier-bound steroids. Similar to the clearance of cholesterol via lipoproteins, these pathways involve the recognition of carrier proteins by endocytic receptors on the surface of target cells, followed by internalization and cellular delivery of the bound sterols. Here, we discuss the emerging concept that steroid hormones can selectively enter steroidogenic tissues by receptor-mediated endocytosis; and we discuss the implications of these uptake pathways for steroid hormone metabolism and action in vivo.
Keywords:Endocytosis, Steroid Carriers, Megalin, Vitamin D Metabolism, Animals
Source:Molecular and Cellular Endocrinology
ISSN:0303-7207
Publisher:Elsevier
Volume:316
Number:1
Page Range:93-102
Date:5 March 2010
Additional Information:The original publication is available at www.springerlink.com
Official Publication:https://doi.org/10.1016/j.mce.2009.07.021
PubMed:View item in PubMed

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