Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction

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Item Type:	Article
Title:	Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction
Creators Name:	Zhang, Y., Tomann, P., Andl, T., Gallant, N.M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M.L., Morrisey, E.E., Overbeek, P.A., Scheidereit, C., Millar, S.E. and Schmidt-Ullrich, R.
Abstract:	Wnt/{beta}-catenin and NF-{kappa}B signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/{beta}-catenin signaling requires epithelial beta-catenin activity. We find that Wnt/{beta}-catenin signaling is absolutely required for NF-{kappa}B activation, and that Edar is a direct Wnt target gene. Wnt/{beta}-catenin signaling is initially activated independently of EDA/EDAR/NF-{kappa}B activity in primary hair follicle primordia. However, Eda/Edar/NF-{kappa}B signaling is required to refine the pattern of Wnt/{beta}-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-{kappa}B signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-{kappa}B target. These data reveal a complex interplay and interdependence of Wnt/{beta}-catenin and EDA/EDAR/NF-{kappa}B signaling pathways in initiation and maintenance of primary hair follicle placodes.
Keywords:	DEVBIO, SIGNALING, Animals, Mice
Source:	Developmental Cell
ISSN:	1534-5807
Publisher:	Cell Press
Volume:	17
Number:	1
Page Range:	49-61
Date:	21 July 2009
Additional Information:	The original publication is available at www.sciencedirect.com
Official Publication:	https://doi.org/10.1016/j.devcel.2009.05.011
PubMed:	View item in PubMed

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