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Plasma HER2 levels are not associated with cardiac function or hypertrophy in control subjects and heart failure patients

Item Type:Letter
Title:Plasma HER2 levels are not associated with cardiac function or hypertrophy in control subjects and heart failure patients
Creators Name:Posch, M.G. and Panek, A. and Kersten, A. and Ghadge, S.K. and Geier, C. and Richter, S. and Perrot, A. and Gailani, M. and Dietz, R. and Lueftner, D. and Oezcelik, C.
Abstract:A proper interaction between the endocardial-derived ligand Neuregulin-1 and the myocardial "Human Epidermal growth factor Receptor 2" (HER2) is essential for maintaining heart function. The shed extracellular domain (ECD) of HER2 circulates in blood and serves as a surrogate marker for breast cancer. Altered cardiac loading conditions are accompanied by dysregulation of the myocardial HER2 gene expression. We studied 193 controls with preserved ejection fraction (EF>55%) and 572 patients with different degrees of systolic heart failure: 98 had EF 45-55%, 138 patients EF 35-44%, and 336 patients, EF <35%, respectively. The corresponding mean HER2 levels were 6.44+/-0.46 ng/mL, 6.07+/-0.76 ng/mL and 6.57+/-0.87 ng/mL, and 6.17+/-0.71 ng/mL, respectively. Furthermore, there was no significant association between plasma HER2 levels and left ventricular filling pressures or the left ventricular wall thickness. The HER2 plasma levels do not reflect the cardiac function and are therefore not useful as a biomarker for heart failure.
Keywords:HER2, erbB2, Heart Failure, Biomarker
Source:International Journal of Cardiology
ISSN:0167-5273
Publisher:Elsevier (The Netherlands)
Volume:145
Number:1
Page Range:105-106
Date:5 November 2010
Official Publication:https://doi.org/10.1016/j.ijcard.2009.05.056
PubMed:View item in PubMed

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