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| Item Type: | Article |
|---|---|
| Title: | Compounds used for 'Injection Lipolysis' destroy adipocytes and other cells found in adipose tissue |
| Creators Name: | Janke, J., Engeli, S., Gorzelniak, K., Luft, F.C. and Jordan, J. |
| Abstract: | Background: A widely applied technique to reduce subcutaneous fat pad size involves subcutaneous injection of a phosphatidylcholine preparation ('injection lipolysis'). As the mode of action is mostly unknown, we planned to study cellular effects of the particular drug used in Germany (Lipostabil). Methods: Human preadipocytes, adipocytes, vascular and skeletal muscle cells as well as renal epithelial cells were incubated in the compound, morphological changes were described, and cell vitality was measured. Results: A strong cytolytic effect of the compound was signified by lipid release and acridine orange staining of dying adipocyte nuclei. When the undiluted compound was used, more than 90% of cell death occurred after 90 s in preadipocytes, after 6 min in vascular smooth muscle cells, skeletal myotubes and renal epithelial cells, and after 15 min in adipocytes. Dilution slowed down cytolysis, but still >50% of the cells disappeared during 30 min incubation. Neither osmotic effects nor differences in medium acidity were responsible for cell death. Conclusion: Injection lipolysis with phosphatidylcholine as the major injected compound reduces subcutaneous fat pad size through cell and tissue destruction. Beside the lack of a clear risk-benefit analysis, applying this technique represents off-label drug use and application of a drug by a contraindicated route. |
| Keywords: | Adipocytes, Preadipocytes, Lipoma, Cytolysis, Lipostabil, Phosphatidylcholine |
| Source: | Obesity Facts |
| ISSN: | 1662-4025 |
| Publisher: | Karger |
| Volume: | 2 |
| Number: | 1 |
| Page Range: | 36-39 |
| Date: | February 2009 |
| Official Publication: | https://doi.org/10.1159/000193461 |
| PubMed: | View item in PubMed |
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