Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

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Item Type:	Article
Title:	Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
Creators Name:	Heringer-Walther, S., Eckert, K., Schumacher, S.M., Uharek, L., Wulf-Goldenberg, A., Gembardt, F., Fichtner, I., Schultheiss, H.P., Rodgers, K. and Walther, T.
Abstract:	Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I(+) and CD34(+) cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
Keywords:	Angiotensin, CD34, Hematopoietic Stem Cell, Animals, Mice
Source:	Haematologica
ISSN:	0390-6078
Publisher:	Ferrata Storti Foundation
Volume:	94
Number:	6
Page Range:	857-860
Date:	June 2009
Official Publication:	https://doi.org/10.3324/haematol.2008.000034
PubMed:	View item in PubMed

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